Comprehensive 2D Gas Chromatography Combined with Rapid-Scanning Triple Quadrupole Ms: Powerful Tools for the Analysis of Complex Samples

Mariosimone Zoccali, Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Chromaleont srl, Messina, Italy
Luigi Mondello, Dipartimento Di Scienze Chimiche, University Of Messina, Messina, Italy

Among many outstanding GC-based research works, the investigation of the open tubular capillary column and of comprehensive two-dimensional gas chromatography (GC×GC) can be considered, in the present author’s opinion, as the two most important innovations in the GC field. In this respect, the separation-power leaps from the packed to the capillary column, and from the latter to GC×GC, are comparable. The present work is focused on the combination of GC×GC system with rapid-scanning triple quadrupole mass spectrometer. The novel QqQ MS system is capable of operation under high speed conditions, in both full-scan (maximum scan speed: 20,000 amu/s) and multiple reaction monitoring (MRM) modes. Moreover, the QqQ MS instrument can generate simultaneous full scan/MRM data, also in a very rapid manner.