Metabolomics for analysis of clinical samples


Michał Markuszewski, Department of Biopharmacy and Pharmacodynamics, Medical University of Gdansk, Hallera 107, 80-416 Gdansk, Poland, markusz@gumed.edu.pl

Nowadays, due to widespread access to high-throughput, ultrasensitive bioanalytical methods, metabolomics is the most dynamically developing branch of biomedical research. Of particular interest is medical metabolomics, which consists of the determination of qualitative and quantitative metabolite profiles of clinical materials. Among potential applications of metabolomics, special attention has been devoted to the search of pathomechanisms of the diseases and medical diagnostics, allowing detection of diseases at the stage of preliminary laboratory analysis. Taking in mind the vast complexity of the pathophysiological and physiological processes it is not surprising that sets of different metabolites might represent more comprehensively the changes in an organism related to the disease than a single selected compound would.
The leading causes of death globally are cardiovascular diseases (CVD), including hypertension and cancer diseases. There is a need for the development of specific diagnostic methods, more effective therapeutic procedures, as well as drugs, which can decrease the risk of deaths in the course of diseases. For this reason, better understanding and explanation of molecular pathomechanisms of them are essential. In the shown studies, the current status of our finding related to those two major health problems would be presented and discussed.


Abstract Reference & Short Personal Biography of Presenting Author

Prof. Dr. Michał Markuszewski is the head of the Department of Biopharmacy and Pharmacodynamics of the Medical University of Gdańsk since 2016. He has graduated from the Faculty of Pharmacy, the Medical University of Gdańsk in 1995 and obtained a Ph.D. degree under the supervision of Prof. Dr. Roman Kaliszan in 2009. He has got a habilitation degree in pharmaceutical analysis in 2007, and he received the title of professor in 2017. In years 2000-2002 he joined a postdoc position in the group of Prof. Shigeru Terabe at Himeji Institute of Technology (currently University of Hyogo) in Japan. He has got scientific training also in the University of Bremen in Germany, the Eindhoven University of Technology in the Netherlands and Vrije Universiteit Brussel in Belgium. His scientific interest comprises the metabolomics, cancer biomarkers, pharmacokinetics, application of separation techniques for pharmaceutical analysis (LC-MS, GC-MS, CE-MS) and bioinformatics. Author of ca. 120 published peer-reviewed publications. He was invited lecturer during international symposia and conferences (more than 20). He has coordinated/participated in several research projects funded by Polish and international institutions over the past ten years in the areas of metabolomics, pharmaceutical analysis, and analytical chemistry. Prof. Dr. Michał Markuszewski is the author and co-author of more than 120 peer-reviewed, original research papers (May 2019: the overall IF > 300, citations according to Web of Science > 2000 and excluding self-citations > 1900, h-index = 26). In the years 2012-2016 he was the vice-dean of the Faculty of Pharmacy of the Medical University of Gdańsk, and since 2016 prof. Markuszewski is a dean of the Faculty of Pharmacy of the Medical University of Gdańsk.

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