Pharmacokinetics of determined bioactive components in Artemisia capillaris

Wan-Ling Lin, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan (slingr23@gmail.com)

Artemisia capillarisThunb is known as Yin-Chen in traditional herbal medicine. Artemisia capillaris has a wide spectrum of pharmacological properties ranging from the progress of liver dysfunction to the severe cirrhosis and cancer that could be contributed to its verified bioactive compounds. The bioactive components were found having, but not limited to, the properties of anti-oxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor effects. Pharmacokinetics of bioactive compounds in Artemisia capillaris not only illustrated the synergic effects but also provides a guide for effective and efficient use of this herb for health professionals. The main identified constituents included scoparone, capillarisin, scopoletin, capillarin, and chlorogenic acid. The time to the maximum concentration of these compounds was reported from 21 minutes to 39 minutes with the longest half-life of 3.76 hours. These reports of pharmacokinetics support a rapid onset of its therapeutic action in various liver diseases including virus infection, cirrhosis, or cancer. In addition, the harvest time or adding of other herbs to Artemisia capillaris would largely influence the pharmacokinetics of contained bioactive compounds. This study describes the scientific evidence supporting the pharmacokinetics of Artemisia capillaris and its constituents synergically attribute the hepatoprotective activities.

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Abstract Reference & Short Personal Biography of Presenting Author

Wan-Ling Lin is currently an attending physician in the Traditional Medicine Department of Kaohsiung Veterans General Hospital. She is rich in innovation and participates in many types of research. She obtained a master's degree from the Graduate Institute of Integrated Medicine of China Medical University. She was awarded the 2015 Outstanding Clinical Teacher in the Physician Field when she was an attending physician at Eda Hospital. She also served as a member of the Chinese Medicine and Pharmacy Committee of Eda Hospital and a member of the Committee of Traditional Chinese Medicine Clinical Trial Center of Eda Hospital. At the same time, she is also a lecturer in the Ministry of Education.