Development of One-Pot Synthetic Methodologies to Construct Diverse Sized Organic Nanoparticles by Varying Component Ratios

Sukdeb Saha, Chemistry, Ben-Gurion University of the Negev, Beer Sheva, Israel
Illya Rozenberg, Chemistry, Ben-Gurion University of the Negev, Beer Sheva, Israel
Gabriel Lemcoff, Chemistry, Ben-Gurion University of the Negev, Beer Sheva, Israel

The rise of nanotechnology in the last decades has also drawn attention to the concept of pure organic nanoparticles1 and hybrid organic nanoparticles2,3for diverse fields such as organic electronics, catalysis, drug delivery and biotechnology.4 Consequently, the improvement of properties by introduction of new functionalities is a key goal which necessitates novel synthetic methodologies. Also, one of the most significant issues when constructing nanoparticles is size control and ease of synthesis. Thus, the goal of our current project is to develop novel one-pot methodologies for the generation of small/medium sized polymeric organic nanoparticles. This concept is based on three component systems [Terminating unit (T), Junction/Core (J) and Cross linker unit (C)] which in a one-pot protocol may lead to polymeric-organic nanoparticles of different sizes in controlled manner in accordance to the relative ratios of the monomeric units. Herein, we show our first results towards this goal. 

                (1)          Bai, Y.; Xing, H.; Vincil, G. A.; Lee, J.; Henderson, E. J.; Lu, Y.; Lemcoff, N. G.; Zimmerman, S. C. Chemical Science 2014, 5, 2862.

                (2)          Serroni, S.; Campagna, S.; Puntoriero, F.; Di Pietro, C.; McClenaghan, N. D.; Loiseau, F. Chemical Society Reviews 2001, 30, 367.

                (3)          Mavila, S.; Diesendruck, C. E.; Linde, S.; Amir, L.; Shikler, R.; Lemcoff, N. G. Angewandte Chemie International Edition 2013, 52, 5767.

                (4)          Wu, W.; Tang, R.; Li, Q.; Li, Z. Chemical Society Reviews 2014.

Organized & Produced by:

POB 4043, Ness Ziona 70400, Israel
Tel.: +972-8-9313070, Fax: +972-8-9313071