Development of Photosensitizing Compounds with Chemotherapy Activity

Thiago Nogueira Parmesano, Instituto de Química , Instituto de Química de São Carlos/Universidade de São Paulo/IQSC - USP, São Carlos, Brazil
Jean Francisco Rosa Ribeiro, Instituto de Química , Instituto de Química de São Carlos/Universidade de São Paulo/IQSC - USP, São Carlos, Brazil
Carlos Alberto Montanari, Instituto de Química , Instituto de Química de São Carlos/Universidade de São Paulo/IQSC - USP, São Carlos, Brazil
Vanderlei Salvador Bagnato, Física e Ciência dos Materiais, Instituto de Física de São Carlos/Universidade de São Paulo/ IFSC - USP, São Carlos, Brazil

Photodynamic Therapy (PDT) is a promising clinical modality that has been consolidated over the past decades and bringing great advances against tumor cells and resistant microorganisms, in relation to conventional therapy, haven’t presenting collaterals effects, high selectivity and efficiency.  Flavins in general, when irradiated mode can operate in the generation of free radicals or participate in oxidative processes such as oxidation of aromatic substrates and addition of substituents in substrates, depending on the reaction conditions.

In this work, based on mechanism of addition and substitution, we develop compounds formed from strategic metabolites propitious candidates for the reactions, combined with riboflavin. it is believed that when irradiated, they may be able to be converted into analog capable of acting as antimetabolites similar action to commercial important as methotrexate antineoplastic, and Mercaptopurine azauridine, from the vicinity of the target cell, thereby obtaining selectivity in the use of antimetabolite as product of the primary photodynamic action of Flavins. Applying analytical techniques for the analysis and isolation of metabolites, products and proteomics analysis combined with methods of Medicinal Chemistry, in this work we seek to elucidate the mechanisms of action of these analogues of low toxicity and inhibitory effects demonstrated in previous work.

It is a work of Scientific Initiation and part of the work of the Course Completion Bachelor of Chemistry from the University of São Paulo.

Referências Bibliográficas

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