How a Complex Four-Step Synthesis Got Into a Smooth One-Pot Reaction

Gal Suez, Adama Makhteshim Ltd., Beer Sheva, Israel

One-pot reactions are preferable in industry. The need to isolate intermidiates can have a big effect on the price of the target material. By not isolating intermidiates less waste is produced, less solvent can be used and less valuable plant-time is consumed.

Nitropyrazole is a key intermidiate in the synthesis of the fungicide Pyraclostrobin. Its synthesis is achived by several steps. The development of a four-step synthesis, towards the nitropyrazole (see scheme), into a one-pot reaction will be presented as a case study. The presentation will detail the process and its limitations.