the 23th ANNUAL MEETING - CONFERENCE & EXHIBITION
21-22 JANUARY 2020, THE DAVID INTERCONTINENTAL HOTEL, TEL AVIV, ISRAEL |
|
Laboratories Adaptation to HPAPI handlingYossi Shapira, Teva Pharmaceuticals Ltd., Israel (yossi.shapira@teva.co.il ) IS- 1530 –Standard for laboratories (quotation): Even the IS regulation is using the phrase "while handling dangerous elements". What are these dangerous elements? Flammables, explosives, biologicals, toxics and HPAPI. Since I mostly experiencing the pharmaceutical laboratories engineering, a well known fact should be pointed out: the handled chemicals in the laboratory are becoming more potent: exposure to smaller quantities creates non controlled, non-desired, non-selected, pharmacological reactions within the no properly protected chemist's body. Chemists might find themselves endangered. 10 micrograms of this active drugs located in a small vial can hardly be detected by the bare eye. But below 5-7 micrograms level, pharmaceutical ingredients, dyes powder pesticides aerosols might not be detected while still creating pharmaceutical activity if penetrating the non-protected chemist/operator natural barrier. Hydrophilic chemicals are dissolved while penetrating through mucutic tissues to human body blood stream. Hydrophobic powders and solutions can penetrate even through our skin arriving also to the blood stream. Laboratory environment and its exposure to potent drugs is monitored while using units of micrograms contaminant/m3 of inhaled air. You cannot expect to visually detect it. Contaminant particles are in the size is of bacteria!. It is flying in the ambient air flawless, attracted to horizontal and vertical surfaces where it accumulates, it can fall on our benches, floors laboratory equipment and instruments and clothes. It is attracted to surfaces mainly by electrostatic power. You cannot wipe it, the laboratory is not a friendly environment to clean and to decontaminate. We are, the laboratory personnel are the most common contaminant spreading by creating air turbulence and in relation to the accumulated amount of contaminant. According to international companies toxicity/potency regulatory strategy, laboratory/site handled chemicals are divided into 5-6 groups. While the 1st group is the innocent compounds (allowed few thousands microgram of powder in 1 m3 of inhaled air, and the 6th group is of the most potent – less than 1 μgr/m3 inhaled air. Yet we tend to forget to measure surfaces contamination. |
|
Organized & Produced by: |
POB 4043, Ness Ziona 70400, Israel |