QC Run in Metabolomics

Aviran Amir, Biochemistry R&D, Merck Group, Jerusalem, Israel (aviran.amir@merckgroup.com)
Alon Sayer, Biochemistry R&D, Merck Group, Jerusalem, Israel

In order to assess any variations in LC-MS-based metabolomics analysis data, it is recommended to add an additional QC (quality control) sample at the beginning of every analytical experiment batch. In addition, It is recommended that QC sample will be injected every 6-10 injections into the workflow steps . The QC sample evaluates any drifting phenomenon like intensity values, ion suppression, or any changes in the retention time of the material’s peaks in the LC-MS data. The  Metabolites QC Mix was developed in order to help in the LC-MS metabolomics  workflows. By utilizing the QC mix, the user will be able to assess drifting and ion suppression phenomenon. 

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Short Biography of Presenting Author

Aviran Amir Ph.D was in held several positions in Sigma Aldrich that was aquired by Merck KGaA. Currently he is the R&D manager of the biochemitry R&D department in Jerusalem Israel. The team is developing new LC-MS tools, imaging reagents and antibiotics for research.