Recent Advances and Applications in Native MS: From Soluble Proteins to Native Membrane Environments

Dror Chorev, C.T.M. Technologies and Materials Ltd. , Ness Ziona, Israel (drorc@ctm-it.co.il)

Native mass spectrometry aims to characterize the biomolecular properties of large, high-mass, multi-component biomolecular entities such as polymers, DNA, proteins and proteins complexes, while they are intact and as closest to their native state as possible. Recent advances in sample preparation and native MS instrumentation have brought about the development of new approaches that allow for the observation and analysis of exceedingly large biological molecules and their molecular associations in highly complex multi-protein near native environments. In this talk I will present these advancements and their practical applications. 

---

Short Biography of Presenting Author

I obtained a Master's degree in cell biology and cancer research from the Department of Biology in the Technion, a Ph.D. in biochemistry and cell biology from the Weizmann Institute of Science  and then continued for post-doctoral research in the Chemistry Department of the University of Oxford  (UK) in the laboratory of Prof. Carol V. Robinson.

Throughout my career, I developed and pioneered native mass spectrometry approaches to probe protein-protein and protein-small molecule interactions within highly complex multi-component environments derived from different tissues and membrane compartments. These works have culminated in 20 papers published in high impact journals and associated IP. 

As of 2024, I'm the chief scientific officer for the C.T.M. laboratory, which provides native MS services in order to help others creatively solve intractable scientific challenges.