Program

Day 1 – April 5 2016

08:00-9:15

Registration

09:15-09:30

Greetings

09:30-10:10

	Plenary Session
	Hematopoiesis in Steady State and Under Stress Toshio Suda M.D. PhD Kumamoto University, Japan

10:10-10:20

Poster Teasers

10:20-10:50

Coffee Break and Poster Session

10:50 -12:30

Hall A

Hall B

Hall C

Hall D

The Biology of Pluripotency

Hematopoietic and Mesenchymal Stem Cells

Commercialization of Stem Cells Initiatives

Stem Cell Applications in Neural Degenerative Diseases

Chair: Adi Kimchi

Chair: Tsvee Lapidot

Chair: Shai Yarkoni

Chair: Michel Revel

10:50 -11:10

Cap-Independent Protein Translation Controls Cell Fate Decisions in Human Embryonic Stem Cells
Adi Kimchi
Weizmann Institute of Science, Israel

Metabolic Regulation of Blood and Bone Forming Stem Cells: the Role of ROS and Nitric Oxide
Tsvee Lapidot
Weizmann Institute of Science, Israel

Catalyzing Company Development by Exploiting Stem Cell Research Services and Technologies Developed Through Public Private Partnerships – A Danish Perspective
Bjørn Holst
Bioneer, Denmark

Customised Single-Use-Bioreactor for Stem Cell Cultivation
Per Stobbe
PerfuseCell, Denmark

Commercialization of Stem Cell Therapy
Brian Mehling
Blue Horizon International, USA

"Cellect Inside" – the Way to Develop Disruptive Technology
Tal Almog
Cellectbio, Israel

The commercialization session will bring together KOLs from Denmark, Belgium, US and Israel to discuss different types of ventures and their adaptability to stem cells technologies: Disruptive technologies, innovative products, services and combinations. Company presentations will be followed by panel discussion on the special features typical to cell (and stem cells in particular) based commercialization

panel

Basic Aspects of Translational Issues in Cell Therapy to the CNS
Tamir Ben Hur
Hadassah Hebrew University Medical Center, Israel

11:10 -11:30

Using Patients' Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Investigating Inherited Cardiac Pathologies
Ofer Binah
Technion, Israel

Vascular Stem Cell Niches
Eli Keshet
Hadassah Hebrew University Medical Center, Israel

Intrathecal Transplantation of Human Astrocytes Attenuates Clinical Symptoms in SOD1^G93A ALS Rat Model
Michal Izrael
Kadimastem Ltd., Israel

11:30 -11:50

Molecular Mechanisms for Inducing and Resolving Pluripotency
Jacob Hanna
Weizmann Institute of Science, Israel

Mesenchymal Stem Cells Sensing Mechanical Cues at Microenvironment
Dafna Benayahu
Tel Aviv University, Israel

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosi
Yael Gothelf
BrainSTorm-Cell Therapeutics Ltd., Israel

11:50 -12:10

Pluripotent Genes and Pediatric Cancer Formation
Achia Urbach
Bar-Ilan University, Israel

Transcription-Factors are Driving to Normal and Malignat Stem Cells
Roi Gazit
Ben-Gurion University of the Negev, Israel

Enhancement of Hippocampal Neurogenesis in the Adult and Aged Brain via Conditional Manipulations of the Vascular Stem Cell Niche
Tamar Licht
The Hebrew University of Jerusalem, Israel

12:10 -12:30

Complete Nuclear Reprogramming Independently of Pluripotency
Yossi Buganim
The Hebrew University of Jerusalem, Israel

Live Imaging of Multipotent Angioblasts Reveals New Mechanisms of Vascular Formation
Karina Yaniv
Weizmann Institute of Science, Israel

Comments on Stem cells in ALS therapy
Michel Revel
Kadimastem Ltd., Israel

12:30 -12:45

Annual Meeting of the ISCS

12:30 -13:30

Lunch break

Hall A

Hall B

Hall C

Hall D

Tissue Regeneration and Stem Cells

Stem Cells in Neurobiology

Cancer Immunotherapy

Drug Discovery and Disease Modeling

13:30 -15:10

Chair: Raphael Gorodetsky

Chair: Benjamin E. Reubinoff

Chair: Michal Besser

Chair: Arik Hasson

13:30 -13:50

Treatment with Isolated Subpopulation of Potent Human Derived Expanded Placental Stromal Cells (hPSC) for Mitigation of Radiation Effects and for Regenerative Medicine
Raphael Gorodetsky
Hadassah Hebrew University Medical Center, Israel

Human Pluripotent Stem Cells Towards Clinical Applications
Benjamin Reubinoff
Hadassah Hebrew University Medical Center, Israel

Adoptive Cell Therapy for Cancer
Michal Besser
Sheba Medical Center, Israel

Novel Approach for Personalized Medicine of Rare Diseases
Miguel Weil
Tel Aviv University, Israel

13:50 -14:10

The Dark Side of the Force: Mesenchymal Stromal Cells in Cardiac Inflammation and Fibrosis
Yoni Leor
Sheba Medical Center, Israel

Molecular and Functional Deficiencies in Fragile X Neurons Derived from Human Embryonic Stem Cells
Dalit Ben-Yosef
Tel Aviv Sourasky Medical Center, Israel

Personalized T Cell-Based Immunotherapy Targeting Neoantigens for Advanced Cancer Treatment
Cyrille Cohen
Bar-Ilan University, Israel

The Use of Patient-Specific Induced Pluripotent Stem Cell Derived Cardiac Myocytes for Disease Modeling and Drug Screening
Naim Shaheen
Technion, Israel

14:10 -14:30

Mesenchymal Stromal Cells and Their Secreted Exosomes Exert Therapeutic Impact in Brain Tumors and Degenerative Diseases va the Delivery of Non-Coding RNAS
Chaya Brodie
Bar-Ilan University, Israel

Streamlined Derivation of Cortical Fates From Human Pluripotent Stem Cells Allows Standardized Modeling of Development and Disease
Yechiel Elkabetz
Tel Aviv University, Israel

New Genes for Improving Safety and Clinical Efficacy of Adoptive T Cell Transfer in Cancer Immunotherapy
Gidi Gross
Migal, Israel

Modeling Neuroendcrinological Disorders Using a Novel iPSC-Based Blood Brain Barrier-on-Chip
Gad Vatine
Cedars-Sinai Medical Center, USA

14:30 -14:50

A Novel Approach for Llung Regeneration by Lung Progenitors Following Clearance of the Lung Niche
Chava Rosen
Weizmann Institute of Science, Israel

Life-Long Hippocampal Neurogenesis is Controlled by the Immune System through Unique Brain's Borders: Implications to Age-Related Dementia
Michal Schwartz
Weizmann Institute of Science, Israel

Fighting Cancer by Mimicking the Immune System
Mira Peled-Kamar
Applied Immune Technology (AIT), Israel

Colony Forming Unites - Endothelial Progenitor Cells (CFU-EPCs) – A Surrogate Marker for Diabetic Retinopathy and High Cardiovascular Mortality
Arnon Blum
Bar-Ilan University, Israel

14:50 -15:10

Oral Mucosa Derived Stem Cell Cells: From Basic Science to Translational Studies
Sandu Pitaru
Tel Aviv University, Israel

Long Lasting Effect of Mesenchymal Stem Cells in BTBR Autism Model in Mice
Danni Offen
Tel Aviv University, Israel

A Novel Method for Enhancing Ex Vivo Expansion of Immunotherapeutic Gamma Delta T Cells
Ilan Bank
Sheba Medical Center and Gammacell Biotechnologies, Israel

Identification of Function-Specific Pancreatic Progenitors by Cell-Based Proteomics
Yoav Soen
Weizmann Institute of Science, Israel

15:10 -15:40

Coffee Break

15:40 -16:20

	Plenary Session
	Functional Neurogenesis in a Dish: Deriving Human and Mouse Networked Neuron Cultures for Therapeutic Screening and Regenerative Therapies Patrick McNutt PhD United States Army Medical Research Institute of Chemical Defense, USA

16:20 -16:30

Poster Teasers

16:30 -17:30

Day 2 – April 6 2016

08:00-09:30

Registration

09:30-10:10

	Plenary Session
	CCRM: Regenerative Medicine Commercialization Through Global Collaboration Michael May, PhD Centre for Commercialization of Regenerative Medicine, Canada

10:10-10:40

Coffee Break and Poster Session

10:40 -12:20

Hall A

Hall B

Hall C

Hall D

Stem cells in Tissue Engineering

Pluripotent Stem Cells in Disease

Regulation, Quality and Clinical Development

Stem Cell Applications in Metabolic Diseases

Chair: Smadar Cohen

Chair: Nissim Benvenisty

Chair: Sigalit Ariely-Portnoy

Chair: Yuval Dor

10:40 -11:00

Stem Cells in Tissue Engineering
Smadar Cohen
Ben-Gurion University, Israel

Haploid Human Embryonic Stem Cells
Nissim Benvenisty
The Hebrew University, Israel

Cell Therapy Submissions in Europe: Successes and Failures
Marcos Timon
AEMPS, Spain

Cell Therapy for Diabetes: Human Embryonic Stem-Cells Derived Functional Insulin Producing Cells
Kfir Molakandon
Kadimastem Ltd., Israel

11:00 -11:20

Regulation of Cardiomyocyte Differentiation and Dedifferentiation Induced by Varying Matrix Rigidity
Benny Geiger
Weizmann Institute of Science, Israel

The Origin, Fate & Regulation of Stem Cells of the Corneal Epithelium: Lessons from iPS Cells and Lineage Tracing
Ruby Shalom
Technion, Israel

Cell Therapy Products: Israeli MOH - Regulatory Update
Ofra Axelrod
MOH, Israel

Beta-Cell Replication: the Role of the Pancreatic Microenvironment
Limor Landman
Tel Aviv University, Israel

11:20 -11:40

The Matrix Reloaded: Engineering Functioning Tissue using Nature’s Building Blocks
Marcelle Machluf
Technion, Israel

Using Patient-Specific Fibroblasts and iPSC-Derived Cardiomyocytes to Probe Monogenic Heart Diseases
Rivka Ofir
Ben Gurion University of the Negev, Israel

Conclusions from Case studies: 10 Points to Consider when Developing a Cell Therapy Product
Diana Gershtein
GSAP, Israel

Industrialization of a Cell Based Autologous Therapy Targeting Diabetes: Industrialization of Liver Cell Amplification Process from Culture Dish to Xpansion™ Multi-Plate Bioreactor
Sara Ferber
Orgenesis, Israel

11:40 -12:00

Microgel Suspension Culture System for hMSCs Bioprocessing
Dror Seliktar
Technion, Israel

Differential Methylation of the GGGGCC Repeat Expansion between C9/ALS HESCs and Patient-Derived iPS Cells
Rachel Eiges
The Hebrew University of Jerusalem, Israel

The “Yellow Brick Road” to Methods Validation for Human Cell Therapy Products
Ruth Goldberg
Pluristem, Israel

Development of an Endocrine Micro-Pancreas
Eduardo Mitrani
The Hebrew University of Jerusalem, Israel

12:00 -12:20

Cardiac Tissue Engineering: from Development of Engineered Autologous Tissues to the Fabrication of Bionic Hearts
Sharon Fleischer
Tel Aviv University, Israel

Latent Infection and Reactivation of the Human-Specific Pathogenic Virus Varicella Zoster using hESC-Derived Neurons- an in-Vitro Model for Herpes Zoster (Shingles)
Ron Goldstein
Bar-Ilan University, Israel

Risk Based Thinking in Shipping Logistics
Ilana Avhar
World Courier, Israel

The βAir Immune Barrier, A Potent Machinery for Protecting Xenogeneic Islets and Stem-Cell Based β-cells from Host Immune Systemβ-cells from Host Immune System
Uriel Barkai
ßeta-O2 Technologies Ltd. Israel

12:30 -13:30

Lunch break

Hall A

Hall B

Hall C

Hall D

Programming of Adult Tissues

Epigenetics of Stem Cells

Combination Products:
Cells, Genes and Devices
In collaboration with

Biology and Translation of Cell Technologies

13:30 -15:10

Chair: Sara Ferber

Chair: Yehudit Bergman

Chair:
Yael Porat, Ohad Karnieli

Chair: Yaron Fuchs

13:30 -13:50

Generating Insulin Producing Cells by Transcription Factor-Induced Lliver Cell Transdifferentiation
Sara Ferber
Orgenesis / Sheba Medical Center, Israel

Epigenetic Programming of Stem Cell Fate Decisions
Yehudit Bergman
The Hebrew University of Jerusalem, Israel

Bringing Cell Therapies to Every Clinic - Vision and Practical Means
Yael Porat (10min)
BioGenCell Ltd, Israel

Devises as a Tool to Standardize Cell and Gene Therapy - New Means to Make Cell Therapy Widely Available
Ohad Karnieli (10 min)
Karnieli Ltd, Israel

Next Generation Cell Therapy Manufacturing
Eytan Abraham (15 min)
Lonza, USA

Engineering of Vascularized Flap Using Human Adipose Derived Endothelial Cells and Mesenchymal Stem Cells
Yulia Shandalov (15 min)
Technion, Israel

Laser Stimulated Stem Cells in the Bone Marrow has Beneficial Effect on the Ischemic Heart and Kidney–a Bench to Bedside Study
Uri Oron (15 min)
Tel Aviv University, Israel

Challenges in Developing Serum-Free Xeno-Free Differentiation Media for hMSC from Various Sources Toward Cell Therapy
Mira Genser-Nir (15 min)
Biological Industries, Israel

Israeli Activity in the International ISO TC276 Standards for Biotechnology
Sagi Nahum (15 min)
Pluristem, Israel

SEPT4/ARTS Regulates Stem Cell Apoptosis and Skin Regenration
Yaron Fuchs
Technion, Israel

13:50 -14:10

Stem Cells are Key Players in Novel Skeletal Therapies
Dan Gazit
The Hebrew University of Jerusalem, Israel

Epitranscriptomics - the Roles of mRNA Modification in Early Embryonic Cell Fate Decisions
Sharon Moshkovitz
Sheba Medical Center, Israel

Metabolic Shifts in the Developing Tissue: A Potential Non-Genetic Means for Regulation of Cell Specification
Arieh Moussaieff
The Hebrew University of Jerusalem, Israel

14:10 -14:30

Programming the Adult Human Kidney
Benny Dekel
Sheba Medical Center, Israel

Chromatin Plasticity in Early Embryonic Stem Cell Differentiation: Imaging and in Silico Approaches
Eran Meshorer
The Hebrew University of Jerusalem, Israel

Higher Genomic Stability of Mesenchymal Stem Cells Cultured for Regenerative Purposes: Lessons From the Tissue Specific Nature of Cells Isolated from Different Adult Sources
Nir Shani
Tel Aviv Sourasky Medical Center, Israel

14:30 -14:50

The Fragile Identity of Pancreatic Beta Cells
Yuval Dor
The Hebrew University of Jerusalem, Israel

Epigenetic Predisposition to Reprogramming Fates
Iftach Nachman
Tel Aviv University, Israel

Computer-Based Assessment of Embryo Quality for Infertility Clinical Applications
Amnon Buxboim
The Hebrew University of Jerusalem, Israel

14:50 -15:10

MicroRNAs Regulate Beta Cell Identity and Function
Eran Hornstein
Weizmann Institute of Science, Israel

Large Scale Analysis of Loss of Imprinting in Human Pluripotent Stem Cells
Shiran Bar
Hebrew University, Jerusalem, Israel

Mechanism of Action Placental-Derived Cellular Therapy for the Treatment of Peripheral Artery Disease
Racheli Ofir
Pluristem, Israel

15:10 -15:40

Coffee Break

15:40 -16:20

	Plenary Session
	Blood Stem Cells in Space and Time Dr Simón Méndez-Ferrer Department of Haematology, University of Cambridge, UK

16:20 -16:30

Announcement of Winning Posters
Closing Remarks

Poster Session

1	Microrna-9a Regulates Aging of Germ Line Stem Cells Through N-Cadherin Yoni Epstein, Human Biology, University of Haifa, Haifa, Israel

2	MicroRNAs in the Stem Cell Niche - the Key for Cellular Longevity Marina Volin, Human Biology, University of Haifa, Haifa, Israel

3	In-House Preparation of DMEM from Powder: a Case Study in Cell Therapy Process Development Yonatan Levinson, Pluristem Therapeutics, Haifa, Israel

4	The Process Is The Product: A Novel Fully Automated, Controlled, Monitored and Scalable 2D Expansion System for Asc’s Dotan Hoffman, Pluristem Therapeutics Ltd., Haifa, Israel

5	Bringing Cell Therapy up to Patient Bed Side – the Development of an Automated and Controlled Point of Care Cell Thawing Device Anna Zaretsky Rits, Development, Pluristem Therapeutics, Haifa, Israel

6	Mechanism of Action of PLX-PAD Cells in Muscle Regeneration Dana Fuchs-Telem, Pluristem Ltd., Haifa, Israel

7	The Radio-Mitigating Effect of PLX-R18, a Placenta -Derived Cellular Therapy, in Hematopoetic Acute Radiation Syndrome Pinzur Lena, Pluristem Ltd. Haifa, Israel

8	MiR-184 Promotes Keratinocyte Adhesion as Essential Part of the Differentiation Process and Barrier Formation Friederike Leesch, Technion - Israel Institute of Technology, Haifa, Israel

9	Regulation of Pax6 and Sox2 in Eye Morphogenesis and Corneal Homeostasis by MIR450 Swarnabh Bhattacharya, Technion - Israel Institute of Technology, Haifa, Israel

10	MiR-184 Represses Keratinocyte Proliferation And Induces Stem Cell Differentiation Sara Nagossa, Technion - Israel Institute of Technology, Haifa, Israel

11	Ras as a Switch between “Naïve” and “Primed” States of Pluripotency Anna Altshuler, Technion - Israel Institute of Technology, Haifa, Israel

12	Extracellular Matrix-Based Gels as Cell Platform for Cardiac Regeneration Yael Efraim, Technion - Israel Institute of Technology, Haifa, Israel

13	Liquefied Pancreatic ECM: a Novel Encapsulation Platform for Diabetes Therapy Stasia Krishtul,Technion - Israel Institute of Technology, Haifa, Israel

14	Nano-Ghosts for Selective Drug Delivery to and Across the Blood Brain Barrier Noa Cohen Anavy, Technion - Israel Institute of Technology, Haifa, Israel

15	Tropoelastin coated porous scaffolds enhance vascular network formation of adipose derived endothelial and mesenchymal stem cells Shira Landau, Technion - Israel Institute of Technology, Haifa, Israel

16	Forces and regulation of vascular network Shira Landau, Technion - Israel Institute of Technology, Haifa, Israel

17	Flow bioreactor for on-line imaging of vasculogenic dynamic in 3D engineered tissue Barak Zohar, Technion - Israel Institute of Technology, Haifa, Israel

18	Disease modeling and potential therapies for skin/corneal pathology: A lesson from pluripotent stem cells and mouse models. Waseem Nasser, Technion - Israel Institute of Technology, Haifa, Israel

19	Human Endothelial Cells Isolated from an Adult Vein Form Vessel Networks within Engineered Muscle Grafts Luba Perry, Technion - Israel Institute of Technology, Haifa, Israel

20	Adipogenesis of 3T3L1 Cells Subjected to Tensile Deformation under Various Glucose Concentrations Maayan Lustig, Tel Aviv University, Tel Aviv, Israel

21	The Epigenetic Characterization of Liver to Endocrine Pancreas Transdifferentiation Adi Har-Zahav, Tel Aviv University, Tel Aviv, Israel

22	The Common Transcriptome Signature of Human and Murine Oral Mucosa-Derived Stem Cells Ina Arie, Tel Aviv University, Tel Aviv, Israel

23	A Platform to Identify, Isolate and Target Cancer Stem Cells Using Late-Passage Patient-Derived Xenograft Model: Malignant Rhabdoid Tumor as an Example Revital Caspi, Tel Aviv University, Tel Aviv, Israel

24	DAP5-Dependent Translation is Required for Human Embryonic Stem Cell Differentiation Yael Yoffe, Weizmann Institute of Science, Rehovot, Israel

25	The Role of miRNAs in Adult Cells Reprogramming along the Endocrine Pancreatic Lineage Alex Osnis, TAU/Sheba Medical Center, Hod Ha Sharon, Israel

26	Reprogramming of Human Somatic Cells into Pluripotent Stem Cells (iPSC) and Gene-Editing to Build Disease Specific in Vitro Models Bjørn Holst, Bioneer A/S, Hoersholm, Denmark

27	Embryonic Stem Cells in Science and Agriculture Sharon Schlesinger, Hebrew University, Rechovot, Israel

28	Mesenchymal stem cells and their derived exosomes exert therapeutic effects in Duchenne muscular dystrophy in mouse and in vitro models Ariel Bier, Bar-Ilan , Ramat-Gan University, Israel

29	Heart Failure Environment Switches Resident and Transplanted Mesenchymal Stromal Cells Toward a Pro-Inflammatory Phenotype and Impairs Their Reparative Properties via Toll Like Receptor-4 Nili Naftali-Shani, Tel-Hashomer, Israel

30	Spontaneous Single-Copy Loss of TP53 in Human Embryonic Stem Cells Markedly Increases Cell Proliferation and Survival Hadar Amir, Tel Aviv Sourasky Medical center, Tel Aviv, Israel

31	Isolated Subpopulation of Highly Potent Human Derived Expanded Placental Stromal Cells (hPSC) in Regenerative Medicine and for Mitigation Acute Lethal Radiation Syndrome Evgenia Volinsky, The Hebrew University of Jerusalem, Jerusalem, Israel

32	The NK killer receptor Ncr1 shapes tumor architecture to prevent metastasis Ariella Glasner, The Hebrew University of Jerusalem, Jerusalem, Israel

33	Reversion of FMR1 methylation and silencing by editing the triplet repeats in Fragile-X iPSC-derived neurons Tomer Halevy, The Hebrew University of Jerusalem, Jerusalem, Israel

34	Derivation and Differentiation of Haploid Human Embryonic Stem Cells Ido Sagi, The Hebrew University of Jerusalem, Jerusalem, Israel

35	Unbiased Screening For Chemotherapy Resistance Genes Using Haploid Human Embryonic Stem Cells Mordecai Peretz, The Hebrew University of Jerusalem, Jerusalem, Israel

36	VEGF is Both Essential and Sufficient for Increasing Overall Hematopoietic Output via Generating Stable Extra-Medullary Stem Cell Niches Myriam Grunewald, Dev Biol & Cancer Res, Hebrew University, Jerusalem, Israel

37	Engineering of Contractile Human Cardiac Tissue from Pluripotent Stem Cell-derived Cardiomyocytes in a Chemically-defined 3D Culture Dana Hayoun-Neeman, Ben Gurion University of the Negev, Beer-Sheva, Israel

38	Ex-Vivo Induced Regulatory Human/Murine Mesenchymal Stem Cells as Immune Modulators Osnat Almogi-Hazan, Hadassah University Hospital, Jerusalem, Israel

39	Human Bone Marrow Mesenchymal Stromal Cells Derived Exosomes as Immunomodulators – Molecular Mechanisms Drirh Khare, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

40	Generation of Clinically Compatible and Genetically Stable iPS Cell Lines from Human Peripheral and Cord Blood Using Microrna-Facilitated Srrna Reprogramming Brad Hamilton, Stemgent, USA

Program Sessions

The organizing committees will consider abstracts for oral and poster presentations on the following topics:

Basic Science:

Translational and Clinical Research:

The Biology of Pluripotency
Hematopoietic and Mesenchymal Stem Cells
Pluripotent Stem Cells in Disease
Stem cells in Tissue Engineering
Epigenetics of Stem Cells
Programming of Adult Tissues
Stem Cells in Neurobiology
Tissue Regeneration and Stem Cells

Translation – New Technologies and Products
Commercialization of Stem Cells Initiatives
Combination Products: Cells, Genes and Devices
Cancer Immunotherapy
Regulation, Quality and Clinical Development
Connective Tissues, Orthopedics and Tissue Engineering
Stem Cell Applications in:
- Cardiac and Vascular Diseases
- Metabolic Disorders and Diabetes
- Neural Degenerative Diseases
Drug Discovery and Disease Modeling

For more information and questions please contact Reut Lazar by phone +972-(0)8-931-3078 or e-mail reutl@bioforum.co.il

Organizer & Producer

Program

Day 1 – April 5 2016

Day 2 – April 6 2016

Poster Session

Program Sessions

Basic Science:

Translational and Clinical Research: